High fractional exhaled nitric oxide may predict response to inhaled corticosteroid therapy in patients with subacute cough
To evaluate fractional exhaled nitric oxide (FENO) level in patients with subacute cough and its value in predicting the patients' response to inhaled corticosteroids (ICS) treatment. A total of 100 patients with persistent cough lasting more than 3 weeks were enrolled, including 52 patients wi...
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Published in | Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 36; no. 7; p. 932 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | Chinese |
Published |
China
20.06.2016
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Subjects | |
Online Access | Get more information |
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Summary: | To evaluate fractional exhaled nitric oxide (FENO) level in patients with subacute cough and its value in predicting the patients' response to inhaled corticosteroids (ICS) treatment.
A total of 100 patients with persistent cough lasting more than 3 weeks were enrolled, including 52 patients with subacute cough and 48 with chronic cough. FENO, spirometry, and responses to ICS therapy of the patients were evaluated.
The recruited patients had a median (inter-quartile ranges) FENO level of 19 ppb (12-30 ppb). Patients with chronic cough had a significantly higher median FENO level than those with subacute cough (20.5 vs 16 ppb; Z=-2.245, P=0.025). A FENO level ≥25 ppb was recorded in 15 (28.8%) patients with subacute cough, as compared with 20 (41.6%) in patients with chronic cough (χ(2)=1.801, P=0.179). With a FENO ≥25 ppb as the critical value to justify ICS treatment, 15 patients with subacute cough received ICS and 14 (93.3%) of them showed obvious relief of cough after 2 weeks of therapy, a response rate s |
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ISSN: | 1673-4254 |