Clinical Features of 46 Multiple Myeloma Patients with Different Renal Pathology

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 24; no. 2; p. 487
• Main Authors: Su, Yu-Tai, Xie, Xin-Sheng, Sun, Hui, Ma, Jie, Wan, Ding-Ming, Liu, Yan-Fang
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2016
• Subjects: Amyloidosis - diagnosis; Amyloidosis - pathology; Humans; Kidney - pathology; Kidney Diseases - diagnosis; Kidney Diseases - pathology; Multiple Myeloma - diagnosis; Multiple Myeloma - pathology; Prognosis; Retrospective Studies
• ISSN: 1009-2137
• DOI: 10.7534/j.issn.1009-2137.2016.02.034

To explore the clinical features of multiple myeloma with different renal pathology, and to evaluate its prognosis. Clinical features and prognosis of 46 multiple myeloma patients with different renal pathology were analyzed retrospectively. According to renal pathology, the 46 patients were divided into 3 groups: cast nephropathy (24 cases), amyloidosis (15 cases) and other type (7 cases). By durie-Salmon staging system, 70.8% cases (17/24) in the cast nephropathy group were in Phase III, 90.9% (20/24) were in subtype B, while in amyloidosis group 53.3% (8/15) were in Phase I, 40% (6/15) were in subtype B, and in other types group, 71.4% (5/7) were in phase III, 57.1% (4/7) were in subtype B, the differences among them were statisticaily significant (P < 0.05). In cast nephropathy group, the monoclonal immunoglobulin could not be detected in 75% (18/24) cases, which was light chain type, while immunoglobulin in amyloidosis and other type groups were mainly IgG type in 73.3% (11/15) and 71.4% (5/7) respective