Research into the Pathogenicity of Enterovirus 71

Enterovirus 71 (EV71) is a major causative agent of hand, foot and mouth disease (HFMD). belongs to family Picornaviridae, genus Enterovirus, species A. EV71 infection usually affects subjects aged <5 years. HFMD caused by EV71 infection is usually mild in children. However, in some cases EV71 in...

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Bibliographic Details
Published inBingdu xuebao Vol. 31; no. 2; p. 192
Main Authors Sun, Lele, Wen, Hongling, Wang, Zhiyu
Format Journal Article
LanguageChinese
Published China 01.03.2015
Subjects
Animals
Enterovirus A, Human - genetics
Enterovirus A, Human - pathogenicity
Enterovirus A, Human - physiology
Hand, Foot and Mouth Disease - virology
Humans
Virulence
Virus Attachment
Virus Replication
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Summary:Enterovirus 71 (EV71) is a major causative agent of hand, foot and mouth disease (HFMD). belongs to family Picornaviridae, genus Enterovirus, species A. EV71 infection usually affects subjects aged <5 years. HFMD caused by EV71 infection is usually mild in children. However, in some cases EV71 infection can lead to severe neurogenic disease and even death. EV71 infection has caused epidemic worldwide (especially in the Asia Pacific). HFMD caused by EV71 has become a major public-health prol lem across the Asia Pacific. In EV71 infection, the pathogenesis is determined by viral and host factor, Here, we review research on host susceptibility and how EV71 suppresses immune and intracellular ri
ISSN:1000-8721