A Case of Combined Use of Mohs Paste and Radiation Therapy for Advanced Breast Cancer with Bleeding

• Published in: Gan to kagaku ryoho Vol. 50; no. 13; p. 1839
• Main Authors: Yanagawa, Takehiro, Yamaura, Minami, Nomura, Hajime, Oshima, Kazuteru, Katsuyama, Shinsuke, Shinke, Go, Kinoshita, Mitsuru, Ikeshima, Ryo, Hiraki, Masayuki, Ohmura, Yoshiaki, Sugimura, Keijiro, Masuzawa, Toru, Hata, Taishi, Takeda, Yutaka, Murata, Kohei
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.12.2023
• ISSN: 0385-0684

A 75-year-old female, at her initial presentation, the tumor occupied her entire right breast, with a foul-smelling exudate. A biopsy revealed ER-positive, HER2-negative breast cancer, and CT revealed multiple lung metastases. Paclitaxel and fulvestrant were administered sequentially, the bleeding from the right breast mass stopped and the mass flattened. But, as the tumor progressed, the right breast mass re-enlarged and began to re-bleed. Therefore, hemostatic treatment with Mohs paste was performed in parallel with tamoxifen. Hemostatic effect was observed for a while, but she gradually became refractory to Mohs paste, necessitating frequent blood transfusions. It was decided to discontinue systemic drug therapy and consider palliative treatment, and to perform radiation therapy in parallel with Mohs paste treatment for the purpose of local control. After radiation therapy, the bleeding has completely stopped and blood transfusion has not to be required for 6 months. Although systemic drug therapy has been discontinued at the patient's request, she is still alive. While systemic drug therapy was discontinued, we were able to confirm the pure local control effect of combination of radiation therapy and Mohs paste.