Research status and challenges of low-level viremia in chronic hepatitis B

Persistent low-level viremia during chronic hepatitis B therapy can promote drug-resistant mutations, liver fibrosis progression and even hepatocellular carcinoma occurrence, which further seriously affect the prognosis of patients. Herein, we hope to clarify and analyze the possible occurrence mech...

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Bibliographic Details
Published inZhonghua gan zang bing za zhi Vol. 29; no. 12; p. 1137
Main Author Hu, P
Format Journal Article
LanguageChinese
Published China 20.12.2021
Subjects
Carcinoma, Hepatocellular
DNA, Viral
Hepatitis B
Hepatitis B virus - genetics
Hepatitis B, Chronic - drug therapy
Humans
Liver Neoplasms
Viremia
Antiviral treatment
Chronic hepatitis B
Low-level viremia
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Summary:Persistent low-level viremia during chronic hepatitis B therapy can promote drug-resistant mutations, liver fibrosis progression and even hepatocellular carcinoma occurrence, which further seriously affect the prognosis of patients. Herein, we hope to clarify and analyze the possible occurrence mechanisms and clinical outcomes of low-level viremia by sorting out the key points, so as to assist in the adjustment of individualized treatment plans and provide references for the diagnosis and treatment.
ISSN:1007-3418
DOI:10.3760/cma.j.cn501113-20211220-00604