Clinical characteristics of patients with chronic thromboembolic pulmonary hypertension

• Published in: Zhong hua yi xue za zhi Vol. 99; no. 44; p. 3461
• Main Authors: Xie, W M, Wang, J, Zhang, S, Wan, J, Tao, X C, Gao, Q, Zhai, Z G, Wang, C
• Format: Journal Article
• Language: Chinese
• Published: China 26.11.2019
• Subjects: China; Chronic Disease; Humans; Hypertension, Pulmonary; Prospective Studies; Pulmonary Embolism; Vascular Resistance; China; Pulmonary embolism; Thromboembolism; Disease Attributes; Hypertension, pulmonary
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2019.44.003

To investigate the clinical characteristics of patients with chronic thromboembolic pulmonary hypertension (CTEPH). CTEPH cases consecutively admitted into China-Japan Friendship Hospital from September 2015 to June 2019 were enrolled with prospective data collection. The medical histories, clinical characteristics, laboratory tests, imaging manifestation and hemodynamic parameters were analyzed. Patients were divided into high pulmonary vascular resistance (PVR) group and low PVR group according to the PVR level>1 000 dyn·s·cm(-5) or not, and clinical characteristics were compared between these two groups. In the 148 cases of CTEPH, right heart catheterization was performed in 103 cases with mPAP (45.1±11.0) mmHg and PVR of (992±430) dyn·s·cm(-5). At diagnosis, 88 (59.5%) cases were in WHO functional class Ⅲ and 27 (18.2%) in class Ⅳ. Most common presenting symptoms were dyspnea (147, 99.3%), chest tightness (68, 45.9%), hemoptysis (42, 28.3%), syncope (30, 20.3%), and most common signs were P2 accentuation