Value of serum matrix metalloproteinase-3 in the assessment of active disease in patients with rheumatoid arthritis

• Published in: Zhong hua yi xue za zhi Vol. 95; no. 47; p. 3823
• Main Authors: Ma, Jianda, Wang, Xiaoying, Mo, Yingqian, Chen, Lefeng, Zheng, Donghui, Wei, Xiuning, Dai, Lie
• Format: Journal Article
• Language: Chinese
• Published: China 15.12.2015
• Subjects: Area Under Curve; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - diagnosis; C-Reactive Protein - analysis; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Matrix Metalloproteinase 3 - blood; ROC Curve; Sensitivity and Specificity
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2015.47.006

To investigate the value of serum matrix metalloproteinase-3 (sMMP-3) in the assessment of active disease in patients with rheumatoid arthritis (RA). One hundred and ninety-one RA patients were recruited from the Department of Rheumatology of Sun Yat-sen Memorial Hospital from June 2010 to June 2014. sMMP-3 level of these RA patients and 58 healthy people was tested by enzyme-linked immunosorbent assay, while clinical data was collected simultaneously. Receiver operating characteristic (ROC) curve was used for the analysis of optimal cut-off point for the evaluation of disease activity. There were 128 female patients and 63 male patients recruited. sMMP-3 was significantly higher in RA patients than healthy control and it was higher in patients with active disease than that in patients in remission (all P < 0.01). ROC curve analysis showed that the optimal cut-off point for diagnosing active RA was 84 μg/L with area under the curve (AUC) 0.822 in female and 168 μg/L with AUC 0.824 in male (both P < 0.01). Acc