Change of white matter neuronal integrity associated with spatial navigation impairment in mild cognitive impairment

• Published in: Zhong hua yi xue za zhi Vol. 97; no. 3; p. 182
• Main Authors: Li, W P, Wang, F F, Lu, J M, Wu, S C, Wu, W B, Liu, R Y, Zhang, X, Li, M, Zhao, H, Zhu, B, Xu, Y, Zhang, B
• Format: Journal Article
• Language: Chinese
• Published: China 17.01.2017
• Subjects: Anisotropy; Brain; Case-Control Studies; Cognitive Dysfunction - pathology; Cognitive Dysfunction - physiopathology; Diffusion Tensor Imaging; Humans; Spatial Navigation; White Matter - pathology; Spatial navigation; Cognition disorders; Perceptual disorders
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2017.03.005

To analyze the correlation between white matter integrity and spatial navigation impairment in patients with mild cognitive impairment (MCI). A total of 27 MCI subjects and 24 healthy controls were enrolled from the Affiliated Drum Tower Hospital of Nanjing University Medical School from May 2015 to February 2016, who underwent 3.0 T MRI scan and 2D-computer version spatial navigation test.DTI preprocessing and tract-based spatial statistics (TBSS) were performed by PANDA.Two sample -test and partial correlation coefficients were performed to investigate the correlation of white matter impairments and spatial navigation decline. Relative to controls, MCI showed worse egocentric navigation ( =-2.202, <0.05). Decreased FA in superior longitudinal fasciculus (left =2.95, right =2.95, <0.05), inferior longitudinal fasciculus and inferior fronto-occipital fasciculus (left =2.66, right =2.96, <0.05), corpus callosum ( =2.09, <0.05), cingulum (left =2.76, right =2.41, <0.05), fornix ( =4.83, <0.05), and corticospina