THE REGULATING EFFECT OF DIPEPTIDES ON CELL PROLIFERATION IN NERVE TISSUE CULTURE IN MAMMALS AND ON ASSOCIATIVE LEARNING IN INSECTS

• Published in: Žurnal ėvolûtsionnoj biohimii i fiziologii Vol. 51; no. 6; p. 440
• Main Authors: Chalisova, N I, Zachepilo, T G, Kamyshev, N G, Lopatina, N G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.11.2015
• Subjects: Animals; Bees - metabolism; Cell Proliferation - drug effects; Dipeptides - pharmacology; Learning - drug effects; Male; Memory - drug effects; Nerve Tissue - metabolism; Rats; Tissue Culture Techniques
• ISSN: 0044-4529

The effect of dipeptides AspPro and AspSer and of their composing amino acids (asparagine acid--Asp, proline--Pro, serin--Ser) on the proliferative activity in the explants of cortex and subcortical structures of the rat brain and on the functional activity of CNS of the honeybee was studied. The square index defined as a proportion of the whole explant square to the square of its central zone was determined. The number of bees responded with the conditional reaction (proboscis extension in the direction to aromatized solution) after 1 min (short-term memory) and 180 min (long-term memory) was detected after single learning procedure. Both dipeptides, as well as the asparagine acid, stimulated an increase of the growth zone of the subcortical structure explants in rats and of the number of honeybees with retention of conditional reaction in the short-term/long-term memory independently of the effect of the second member of the dipeptide. The unidirectionality of the effect suggests the existence of common mechanisms of reception and signal transduction established during evolution that require the further study.