Clinical Features and Prognosis of Acute T-cell Lymphoblastic Leukemia in Children--Multi-Center Data Analysis in Fujian

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 32; no. 1; p. 6
• Main Authors: Wu, Chun-Ping, Zheng, Yong-Zhi, Li, Jian, Wen, Hong, Weng, Kai-Zhi, Zhuang, Shu-Quan, Wu, Xing-Guo, Hua, Xue-Ling, Zheng, Hao, Chen, Zai-Sheng, LE, Shao-Hua
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2024
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Burkitt Lymphoma - drug therapy; Child; Disease-Free Survival; Humans; Male; Neoplasm, Residual - diagnosis; Neoplasm, Residual - drug therapy; Pathologic Complete Response; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; T-Lymphocytes; acute T-cell lymphoblastic leukemia; adverse event; efficacy; child
• ISSN: 1009-2137
• DOI: 10.19746/j.cnki.issn.1009-2137.2024.01.002

To evaluate the efficacy of acute T-cell lymphoblastic leukemia (T-ALL) in children and explore the prognostic risk factors. The clinical data of 127 newly diagnosed children with T-ALL admitted to five hospitals in Fujian province from April 2011 to December 2020 were retrospectively analyzed, and compared with children with newly diagnosed acute precursor B-cell lymphoblastic leukemia (B-ALL) in the same period. Kaplan-Meier analysis was used to evaluate the overall survival (OS) and event-free survival (EFS), and COX proportional hazard regression model was used to evaluate the prognostic factors. Among 116 children with T-ALL who received standard treatment, 78 cases received the Chinese Childhood Leukemia Collaborative Group (CCLG)-ALL 2008 protocol (CCLG-ALL 2008 group), and 38 cases received the China Childhood Cancer Collaborative Group (CCCG)-ALL 2015 protocol (CCCG-ALL 2015 group). The efficacy and serious adverse event (SAE) incidence of the two groups were compared. Proportion of male, age≥10 year