Outcomes of advanced gastric cancer patients treated with chemoradiation therapy

We retrospectively analyzed 20 patients with advanced gastric cancer treated with chemoradiation(CRT). The patients consisted of 16 males and 4 females, 17(85%)of whom received intensive chemotherapy prior to CRT. Radiation was administered concurrently at 40 to 55 Gy according to the purpose of tre...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 40; no. 6; p. 727
Main Authors Ishigami, Sumiya, Arigami, Takaaki, Uenosono, Yoshikazu, Okumura, Hiroshi, Uchikado, Yasuto, Owaki, Tetsuhiro, Kijima, Yuko, Nakajo, Akihiro, Maemura, Kousei, Ueno, Shinichi, Hokita, Shuichi, Hiraki, Yoshikazu, Nakajo, Masataka, Natsugoe, Shoji
Format Journal Article
LanguageJapanese
Published Japan 01.06.2013
Subjects
Adult
Aged
Chemoradiotherapy - adverse effects
Female
Humans
Male
Middle Aged
Neoplasm Invasiveness
Stomach Neoplasms - pathology
Stomach Neoplasms - therapy
Treatment Outcome
Young Adult
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Summary:We retrospectively analyzed 20 patients with advanced gastric cancer treated with chemoradiation(CRT). The patients consisted of 16 males and 4 females, 17(85%)of whom received intensive chemotherapy prior to CRT. Radiation was administered concurrently at 40 to 55 Gy according to the purpose of treatment. Sixteen patients received low dose CDDP and S-1. Of 8 patients who had measurable disease, one obtained CR and 3 obtained PR by the CRT. Fifteen percent of the distinct adverse effects of CRT were grade 3 leucopenia and 30% of them were grade 3 nausea. The 2-year-survival of patients who received CRT with curative intent was 91%, significantly higher than the percentage of those with palliative intent. Four patients who received R0 surgery following CRT are postoperatively healthy without symptoms of relapse. In conclusion, even though, 75% of the patients were already given chemotherapy prior to CRT, good outcomes were achieved unexpectedly. The combination of CRT and surgery may be a useful tool for chemo-resistant, locally advanced gastric cancer.
ISSN:0385-0684