Expression of hypoxia-inducible factor 1α is associated with lymph node metastasis in oral squamous cell carcinoma

• Published in: Beijing da xue xue bao. Journal of Peking University. Yi xue ban Vol. 50; no. 1; p. 26
• Main Authors: Li, J N, Feng, Z E, Wang, L, Wang, Y X, Guo, C B
• Format: Journal Article
• Language: Chinese
• Published: China 18.02.2018
• Subjects: Biomarkers - metabolism; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - pathology; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Immunohistochemistry; Lymph Nodes; Lymphatic Metastasis - genetics; Mouth Neoplasms - genetics; Mouth Neoplasms - pathology; Prognosis
• ISSN: 1671-167X

To explore the association between hypoxia-inducible factor 1α (HIF-1α) expression and lymph node metastasis in oral squamous cell carcinoma (OSCC). Tumor specimens from 125 patients with histologically-proven, surgically-treated OSCC were examined by immunohistochemical staining for expression of HIF-1α. The patients were divided into two groups by the expression of HIF-1α, high expression of HIF -1α group (H-group) and low expression of HIF-1α group (L-group). The main assessment parameters were lymph node metastasis rate and disease-specific survival (DSS). The lymph node metastasis rate and clinicopathologic features were compared using Mann-Whitney test. The Kaplan-Meier curve was generated for each group and compared using the log-rank test. Cox proportional hazard models were utilized for multivariate analyses of HIF-1α expression and other baseline factors with DSS. All calculations and analyses were performed using the SPSS 17.0 software package. The protein expression levels of HIF-1α were up-regula