Significance of CD37 expression in malignant B cells

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 22; no. 3; p. 644
• Main Authors: Wang, Wei, Li, Yan, Gao, Li, Xu, Shao-Hua, Gong, Ming, Huang, Fan-Zhou, Li, Zhen-Ling, Chen, Yan-Rong, Ma, Yi-Gai
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2014
• Subjects: Antigens, Neoplasm - metabolism; Bone Marrow Cells - metabolism; Case-Control Studies; Flow Cytometry; Humans; Lymphoma, B-Cell - metabolism; Lymphoma, B-Cell - pathology; Lymphoma, Non-Hodgkin - metabolism; Lymphoma, Non-Hodgkin - pathology; Tetraspanins - metabolism
• ISSN: 1009-2137
• DOI: 10.7534/j.issn.1009-2137.2014.03.013

The aim of this study was to clarify the clinical significance of CD37 expression in B cells from B acute lymphoblastic leukemia (B-ALL) and B cell non-Hodgkin's lymphoma (B-NHL). The expression level of CD37 on B cells from bone marrow samples of normal controls (n = 19), B-ALL patients [including untreated cases (n = 5) and cases with minimal residual disease (MRD, n = 15)] and B-NHL patients (n = 25) whose bone marrow was involved by lymphoma cells, was detected by multiple parameter flow cytometry. The results indicated that the B cells from both untreated cases and cases with MRD lowly expressed CD37 (1.04 ± 0.24 and 1.50 ± 0.89), the normal precursor B cells (control cases) also lowly expressed CD37 (1.64 ± 0.52). There was no difference of CD37 expression level between 3 groups of cases(P > 0.05). Meanwhile the normal mature B cells and B-NHL cells highly expressed CD37 (14.23 ± 7.84 and 14.53 ± 10.93), but there was no difference of CD37 expression between them (P > 0.05). The comparison of CD37 expre