A Case of Duodenal Perforation during Bevacizumab Combination Chemotherapy in a Patient with Multiple Lung Metastasis after a Sigmoidectomy

A 73-year-old man underwent laparoscopic sigmoidectomy for sigmoid colon cancer. Two years after the operation, multiple lung metastasis was diagnosed and chemotherapy with bevacizumab, irinotecan, and TS-1®was started in the patient. However, epigastric pain developed 73 days after the initial cour...

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Published inGan to kagaku ryoho Vol. 46; no. 5; p. 953
Main Authors Suzumura, Hirofumi, Shinozaki, Hiroharu, Kondo, Rie, Yamaguchi, Masatoshi, Torizaki, Yukiko, Ozawa, Yosuke, Futoh, Yurie, Matsuoka, Tadashi, Matsumoto, Kenji, Inoue, Masazumi, Sasakura, Yuichi, Terauchi, Toshiaki, Kimata, Masaru, Furukawa, Junji, Kobayashi, Kenji, Ogata, Yoshiro
Format Journal Article
LanguageJapanese
Published Japan 01.05.2019
Subjects
Aged
Antineoplastic Combined Chemotherapy Protocols
Bevacizumab - adverse effects
Colon, Sigmoid
Duodenal Ulcer
Humans
Intestinal Perforation
Male
Sigmoid Neoplasms - therapy
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Summary:A 73-year-old man underwent laparoscopic sigmoidectomy for sigmoid colon cancer. Two years after the operation, multiple lung metastasis was diagnosed and chemotherapy with bevacizumab, irinotecan, and TS-1®was started in the patient. However, epigastric pain developed 73 days after the initial course of chemotherapy. Abdominal CT revealed duodenal perforation and generalized peritonitis. Emergency operation with omental patch closure was immediately performed. The patient was discharged 15 days after the emergency operation without any complication. This is an extremely rare case of bevacizu- mab-related duodenal perforation.
ISSN:0385-0684