Clinical Features and Prognosis of t(8;21) AML Patients in China: A Multicenter Retrospective Study

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 25; no. 4; p. 980
• Main Authors: Gong, Dan, Li, Wei, Hu, Liang-Ding, Luo, Jian-Min, Shen, Jian-Liang, Fang, Mei-Yun, Yang, Qing-Ming, Wang, Heng-Xiang, Ke, Xiao-Yan, Chen, Hui-Ren, Wang, Zhao, Liu, Hui, Liu, Feng, Ma, Yi-Gai, Wang, Jing-Wen, Li, Hong-Hua, Wang, Quan-Shun, Jing, Yu, Gao, Xiao-Ning, Dou, Li-Ping, Li, Yong-Hui, Yu, Li
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2017
• Subjects: China; HLA-DR Antigens; Humans; Leukemia, Myeloid, Acute; Prognosis; Retrospective Studies; China
• DOI: 10.7534/j.issn.1009-2137.2017.04.004
• ISSN: 1009-2137

To summarize the clinical characteristics of peripheral blood, immune phenotypes, fusion genes and cytogenetics of patients with t(8;21) acute myeloid leukemia(AML) through the retrospective analysis of 586 patients with t(8;21) AML from 15 blood disease research centers in Northern area of China. The factors affecting prognosis of patients with t(8;21) AML were investigated by using univariate and multivariate COX regression. The immune type of t(8;21) AML patients was mainly with HLA-DR , CD117 , CD34 , MPO , CD38 , CD13 and CD33 (>95%), part of them with CD19 and CD56 ; the most common accompanied mutation of t(8;21) AML patients was C-KIT mutation (37.8%); in addition to t(8;21) ectopic, the most common chromosomal abnormality was sex chromosome deletions (38.9%). The univariate analysis revealed a significant survival superiority of OS and PFS in t(8;21) AML patients of WBC≤3.5×10 /L without C-KIT mutation, the newly diagnosed ones achieved HSCT(P<0.05), only survival superiority on OS in t(8;21) AML pat