Clinical Features and Prognosis of t(8;21) AML Patients in China: A Multicenter Retrospective Study
To summarize the clinical characteristics of peripheral blood, immune phenotypes, fusion genes and cytogenetics of patients with t(8;21) acute myeloid leukemia(AML) through the retrospective analysis of 586 patients with t(8;21) AML from 15 blood disease research centers in Northern area of China. T...
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Published in | Zhongguo shi yan xue ye xue za zhi Vol. 25; no. 4; p. 980 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | Chinese |
Published |
China
01.08.2017
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Abstract | To summarize the clinical characteristics of peripheral blood, immune phenotypes, fusion genes and cytogenetics of patients with t(8;21) acute myeloid leukemia(AML) through the retrospective analysis of 586 patients with t(8;21) AML from 15 blood disease research centers in Northern area of China.
The factors affecting prognosis of patients with t(8;21) AML were investigated by using univariate and multivariate COX regression.
The immune type of t(8;21) AML patients was mainly with HLA-DR
, CD117
, CD34
, MPO
, CD38
, CD13
and CD33
(>95%), part of them with CD19
and CD56
; the most common accompanied mutation of t(8;21) AML patients was C-KIT mutation (37.8%); in addition to t(8;21) ectopic, the most common chromosomal abnormality was sex chromosome deletions (38.9%). The univariate analysis revealed a significant survival superiority of OS and PFS in t(8;21) AML patients of WBC≤3.5×10
/L without C-KIT mutation, the newly diagnosed ones achieved HSCT(P<0.05), only survival superiority on OS in t(8;21) AML pat |
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AbstractList | To summarize the clinical characteristics of peripheral blood, immune phenotypes, fusion genes and cytogenetics of patients with t(8;21) acute myeloid leukemia(AML) through the retrospective analysis of 586 patients with t(8;21) AML from 15 blood disease research centers in Northern area of China.
The factors affecting prognosis of patients with t(8;21) AML were investigated by using univariate and multivariate COX regression.
The immune type of t(8;21) AML patients was mainly with HLA-DR
, CD117
, CD34
, MPO
, CD38
, CD13
and CD33
(>95%), part of them with CD19
and CD56
; the most common accompanied mutation of t(8;21) AML patients was C-KIT mutation (37.8%); in addition to t(8;21) ectopic, the most common chromosomal abnormality was sex chromosome deletions (38.9%). The univariate analysis revealed a significant survival superiority of OS and PFS in t(8;21) AML patients of WBC≤3.5×10
/L without C-KIT mutation, the newly diagnosed ones achieved HSCT(P<0.05), only survival superiority on OS in t(8;21) AML pat |
Author | Chen, Hui-Ren Wang, Jing-Wen Li, Yong-Hui Ma, Yi-Gai Ke, Xiao-Yan Li, Wei Yu, Li Gao, Xiao-Ning Li, Hong-Hua Hu, Liang-Ding Wang, Quan-Shun Jing, Yu Gong, Dan Luo, Jian-Min Fang, Mei-Yun Yang, Qing-Ming Wang, Zhao Liu, Hui Liu, Feng Dou, Li-Ping Shen, Jian-Liang Wang, Heng-Xiang |
Author_xml | – sequence: 1 givenname: Dan surname: Gong fullname: Gong, Dan organization: Department of Hematology, Chinese PLA General Hospital, Beijing 100853,China; Department of Hematology, No.222 Hospital of Chinese PLA, Jilin 132011, Jilin Province,China – sequence: 2 givenname: Wei surname: Li fullname: Li, Wei organization: Department of Hematology, The First Affiliated Hospital of Jilin University, Changchun 130000,Jilin Province, China – sequence: 3 givenname: Liang-Ding surname: Hu fullname: Hu, Liang-Ding organization: Department of Hematology, The Second Affiliated Hospital of Hebei Medical University, Shijia-zhuang 050000, Hebei Province, China – sequence: 4 givenname: Jian-Min surname: Luo fullname: Luo, Jian-Min organization: Department of Hematology, No. 307 Hospital of Chinese PLA, Beijing 100071, China – sequence: 5 givenname: Jian-Liang surname: Shen fullname: Shen, Jian-Liang organization: Department of Hematology, Chinese NAVY General Hospital, Beijing 100037, China – sequence: 6 givenname: Mei-Yun surname: Fang fullname: Fang, Mei-Yun organization: Department of Hematology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China – sequence: 7 givenname: Qing-Ming surname: Yang fullname: Yang, Qing-Ming organization: Department of Diagnosis and Therapy for Carders, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100037, China – sequence: 8 givenname: Heng-Xiang surname: Wang fullname: Wang, Heng-Xiang organization: Department of Hematology, Chinese Air Force General Hospital, Beijing 100142, China – sequence: 9 givenname: Xiao-Yan surname: Ke fullname: Ke, Xiao-Yan organization: Department of Hematology, Peking University Third Hospital, Beijing 100191, China – sequence: 10 givenname: Hui-Ren surname: Chen fullname: Chen, Hui-Ren organization: Department of Hematology, Chinese PLA Army General Hospital, Beijing 100700, China – sequence: 11 givenname: Zhao surname: Wang fullname: Wang, Zhao organization: Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China – sequence: 12 givenname: Hui surname: Liu fullname: Liu, Hui organization: Department of Hematology, Beijing Hospital, Ministry of Health, Beijing 100730, China – sequence: 13 givenname: Feng surname: Liu fullname: Liu, Feng organization: Department of Hematology, Xiyuan Hospital of Chinese Academy of Medical Sciences, Beijing 100091, China – sequence: 14 givenname: Yi-Gai surname: Ma fullname: Ma, Yi-Gai organization: Department of Hematology, China-Japan Friendship Hospital, Beijing 100029, China – sequence: 15 givenname: Jing-Wen surname: Wang fullname: Wang, Jing-Wen organization: Department of Hematology, Beijing Tongren Hospital, Beijing 100730, China – sequence: 16 givenname: Hong-Hua surname: Li fullname: Li, Hong-Hua organization: Department of Hematology, Chinese PLA General Hospital, Beijing 100853,China – sequence: 17 givenname: Quan-Shun surname: Wang fullname: Wang, Quan-Shun organization: Department of Hematology, Chinese PLA General Hospital, Beijing 100853,China – sequence: 18 givenname: Yu surname: Jing fullname: Jing, Yu organization: Department of Hematology, Chinese PLA General Hospital, Beijing 100853,China – sequence: 19 givenname: Xiao-Ning surname: Gao fullname: Gao, Xiao-Ning organization: Department of Hematology, Chinese PLA General Hospital, Beijing 100853,China – sequence: 20 givenname: Li-Ping surname: Dou fullname: Dou, Li-Ping organization: Department of Hematology, Chinese PLA General Hospital, Beijing 100853,China – sequence: 21 givenname: Yong-Hui surname: Li fullname: Li, Yong-Hui organization: Department of Hematology, Chinese PLA General Hospital, Beijing 100853,China – sequence: 22 givenname: Li surname: Yu fullname: Yu, Li email: liyu301@163.com organization: Department of Hematology, Chinese PLA General Hospital, Beijing 100853,China. E-mail:liyu301@163.com |
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Title | Clinical Features and Prognosis of t(8;21) AML Patients in China: A Multicenter Retrospective Study |
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