Clinical Features and Prognosis of t(8;21) AML Patients in China: A Multicenter Retrospective Study
To summarize the clinical characteristics of peripheral blood, immune phenotypes, fusion genes and cytogenetics of patients with t(8;21) acute myeloid leukemia(AML) through the retrospective analysis of 586 patients with t(8;21) AML from 15 blood disease research centers in Northern area of China. T...
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Published in | Zhongguo shi yan xue ye xue za zhi Vol. 25; no. 4; p. 980 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | Chinese |
Published |
China
01.08.2017
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Subjects | |
Online Access | Get more information |
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Summary: | To summarize the clinical characteristics of peripheral blood, immune phenotypes, fusion genes and cytogenetics of patients with t(8;21) acute myeloid leukemia(AML) through the retrospective analysis of 586 patients with t(8;21) AML from 15 blood disease research centers in Northern area of China.
The factors affecting prognosis of patients with t(8;21) AML were investigated by using univariate and multivariate COX regression.
The immune type of t(8;21) AML patients was mainly with HLA-DR
, CD117
, CD34
, MPO
, CD38
, CD13
and CD33
(>95%), part of them with CD19
and CD56
; the most common accompanied mutation of t(8;21) AML patients was C-KIT mutation (37.8%); in addition to t(8;21) ectopic, the most common chromosomal abnormality was sex chromosome deletions (38.9%). The univariate analysis revealed a significant survival superiority of OS and PFS in t(8;21) AML patients of WBC≤3.5×10
/L without C-KIT mutation, the newly diagnosed ones achieved HSCT(P<0.05), only survival superiority on OS in t(8;21) AML pat |
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ISSN: | 1009-2137 |
DOI: | 10.7534/j.issn.1009-2137.2017.04.004 |