Mixed craniopharyngioma: long-term results after gamma knife combined with stereotactic brachytherapy

• Published in: Chung-hua wai kʿo tsa chih Vol. 51; no. 7; p. 631
• Main Authors: Yu, Xin, Zhang, Jian-ning, Liu, Rui, Wang, Ya-ming, Sun, Jun-zhao, Qi, Shu-bin, DU, Ya-nan, Wang, Hong-wei, Zhao, Hu-lin, Liu, Zong-hui
• Format: Journal Article
• Language: Chinese
• Published: China 01.07.2013
• Subjects: Adolescent; Adult; Aged; Child; Child, Preschool; Combined Modality Therapy; Craniopharyngioma - surgery; Female; Follow-Up Studies; Humans; Imaging, Three-Dimensional; Male; Middle Aged; Pituitary Neoplasms - surgery; Radiosurgery; Retrospective Studies; Survival Rate; Treatment Outcome; Young Adult
• ISSN: 0529-5815

To evaluate the long-term results of combination treatment with Gamma Knife radiosurgery and stereotactic intracavitary brachytherapy for mixed cystic and solid craniopharyngiomas. Sixty-seven consecutive patients with mixed cystic and solid craniopharyngioma treated by Gamma Knife radiosurgery combined with stereotactic brachytherapy from October 1996 to December 2005 were selected for retrospective analysis. The inclusion criterion was the patients who survived for at least 5 years after combined treatment. There were 39 male and 28 female patients and the mean age was 31.5 years (ranged from 3 to 70 years). The clinical evaluations including neurological, neuro-ophthalmological, and neuro-endocrinological examinations, assessment of comprehensive quality of life and neuroimaging examinations were performed periodically. The actuarial survival rates and the mean survival time were calculated by using Kaplan-Meier product limit method. The rates were compared using the χ(2) test. Follow-up period varied from