Aberrant expression of long noncoding RNA in prostate cancer

Prostate cancer (PCa) is one of the most common malignant tumors as well as a frequent cause of cancer-related mortality in men worldwide. The test of serum markers has dramatically improved the early diagnosis of PCa, but its underlying molecular mechanisms are not yet completely identified. Long n...

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Bibliographic Details
Published inZhonghua nan ke xue Vol. 21; no. 10; p. 945
Main Authors Wang, Ya-min, Song, Le-bin, Zhang, Jia-yi, Yang, Jie, Song, Ning-hong
Format Journal Article
LanguageChinese
Published China 01.10.2015
Subjects
Humans
Male
Prognosis
Prostatic Neoplasms - metabolism
RNA, Long Noncoding - metabolism
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Summary:Prostate cancer (PCa) is one of the most common malignant tumors as well as a frequent cause of cancer-related mortality in men worldwide. The test of serum markers has dramatically improved the early diagnosis of PCa, but its underlying molecular mechanisms are not yet completely identified. Long noncoding RNA (IncRNA) is emerging as a new player in the PCa paradigm demonstrating its potential roles in both oncogenic and tumor suppressive pathways. LncRNA is frequently aberrantly expressed in the majority of PCa cases. This review highlights recent findings of the aberrant expression of lncRNA in PCa and discusses its novel roles in the diagnosis, prediction, prognosis, metastasis, and potential clinical treatment of PCa.
ISSN:1009-3591