A case of pathologically complete response of local recurrence in the mesorectum after multidisciplinary therapy

The patient was a 68-year-old man who had undergone sigmoidectomy 1 year previously. Adjuvant therapy with tegafur- uraci(l UFT) and Leucovorin( UZEL) was administered. Seven months later, the carcinoembryonic antigen( CEA) level increased to 7.5 ng/mL. Enhanced computed tomography (CT) revealed a 4...

Full description

Saved in:
Bibliographic Details
Published inGan to kagaku ryoho Vol. 40; no. 12; p. 1993
Main Authors Ishiba, Toshiyuki, Ohtsukasa, Shunro, Kato, Shunsuke, Nagano, Hiroto, Takamatsu, Susumu, Taki, Kazuhiro, Hiraoka, Yuu, Murase, Hideaki, Enjoji, Megumi, Ishimaru, Shinya, Ono, Ryo, Kawachi, Yasuyuki, Maruyama, Hiroshi, Sugihara, Kenichi
Format Journal Article
LanguageJapanese
Published Japan 01.11.2013
Subjects
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Chemoradiotherapy
Humans
Male
Rectal Neoplasms - secondary
Rectal Neoplasms - therapy
Recurrence
Remission Induction
Sigmoid Neoplasms - drug therapy
Sigmoid Neoplasms - pathology
Sigmoid Neoplasms - surgery
Online AccessGet more information

Cover

More Information
Summary:The patient was a 68-year-old man who had undergone sigmoidectomy 1 year previously. Adjuvant therapy with tegafur- uraci(l UFT) and Leucovorin( UZEL) was administered. Seven months later, the carcinoembryonic antigen( CEA) level increased to 7.5 ng/mL. Enhanced computed tomography (CT) revealed a 4-cm mass in the mesorectum, and the patient was diagnosed as having local recurrence. Chemotherapy with oxaliplatin, 5-fluorouracil, and Leucovorin( mFOLFOX6) and radiation therapy( 60 Gy) were administered. As the tumor could not be detected after chemoradiotherapy, abdominoperineal resection was performed. Pathological examination showed no cancer and indicated a complete response. The patients CEA level has not increased and no recurrence has been detected on enhanced CT for 3.5 years. The tumor could be decreased in size by chemoradiotherapy and the operation could be safely performed without resecting other organs. Although surgery is generally performed for local recurrence, multidisciplinary therapy could be useful in performing such surgery safely.
ISSN:0385-0684