Antibodies to Hsp60 in newborn babies, to whom during the intervention for critical inborn heart failure, autologous cord blood was transfused, in early and late postoperative period

• Published in: Klinična hìrurgìâ (Kiïv) no. 12; pp. 33 - 36
• Main Authors: Vorobĭova, H M, Tkachenko, Ia V, Iakovenko, L F, Zhovnir, V A, Sydoryk, L L, Iemets', I M
• Format: Journal Article
• Language: Ukrainian
• Published: Ukraine 01.12.2014
• Subjects: Autoantibodies - blood; Biomarkers - blood; Blood Transfusion, Autologous; Chaperonin 60 - blood; Chaperonin 60 - immunology; Cord Blood Stem Cell Transplantation; Factor Analysis, Statistical; Female; Heart Failure - congenital; Heart Failure - immunology; Heart Failure - surgery; Heart Failure - therapy; Humans; Infant, Newborn; Male; Mitochondrial Proteins - blood; Mitochondrial Proteins - immunology; Postoperative Complications - prevention & control; Postoperative Period; Prognosis; Prospective Studies
• ISSN: 0023-2130

The titre of antibodies to Hsp60 (heat shock protein) enhancement in the blood serum is considered a biological marker of poor state of organism. Comparative investigation was done on the antibodies titre to Hsp60 in the blood serum of a newborn babies, suffering critical inborn heart failure, to whom autologous cord blood or the donor's blood components was transfused, in early and remote postoperative period. In early postoperative period the lowering of the antibodies titre to Hsp60 in the blood serum was observed in comparison with them preoperatively, in a late period (in 2 yrs) in all the blood serum samples investigated antibodies to Hsp60 were not revealed. In 35% of patients, to whom the donor's blood components were transfused, there was registered the enhancement of the antibodies to Hsp60 titre in early postoperative period. High titre of antibodies have associated with enhanced rate of complications. In late postoperative period antibodies to Hsp60 were revealed in 20% of the examined patients.