Efficacy of different preparations of budesonide combined with pulmonary surfactant in the treatment of neonatal respiratory distress syndrome: a comparative analysis

• Published in: Zhongguo dang dai er ke za zhi Vol. 18; no. 5; pp. 400 - 404
• Main Authors: Ke, Hua, Li, Zhan-Kui, Yu, Xi-Ping, Guo, Jin-Zhen
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2016
• Subjects: Bronchopulmonary Dysplasia - prevention & control; Budesonide - administration & dosage; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Male; Pulmonary Surfactants - administration & dosage; Respiration, Artificial; Respiratory Distress Syndrome, Newborn - drug therapy
• ISSN: 1008-8830
• DOI: 10.7499/j.issn.1008-8830.2016.05.005

To study the efficacy of different preparations of budesonide combined with pulmonary surfactant (PS) in improving blood gas levels and preventing bronchopulmonary dysplasia (BPD) in preterm infants with neonatal respiratory distress syndrome (NRDS). A total of 184 preterm infants who developed NRDS within 4 hours after birth were randomly administered with PS + continuous inhalation of budesonide aerosol (continuous aerosol group), PS+budesonide solution (solution group), PS + single inhalation of budesonide aerosol (single aerosol group), and PS alone, with 46 neonates in each group. The changes in arterial blood gas levels, rate of invasive mechanical ventilation after treatment, time of assisted ventilation, rate of repeated use of PS, and the incidence of BPD were compared between the four groups. On the 2nd to 4th day after treatment, pH, PCO2, and oxygenation index (FiO2/PaO2) showed significant differences among the four groups, and the continuous aerosol group showed the most improvements of all indi