THE CASE OF T-CELL LARGE GRANULAR LYPHOCYTE LEUKEMIA PRESENTED AS TRANSFUSION DEPENDENT ANEMIA WITH SUSTAINED RESPONSE TO CYC- LOSPORINE A THERAPY: CASE REPORT

A 41-year-old man presented with anemia, lymphocytosis and splenoniegaly. T-cell large granular lymphocyte leukemia was diagnosed based on lymphocytosis of T-cell large granular lymphocytes, characteristic inimunophenotype (CD)3⁺ CD8⁺, CD16⁺, CD57⁺) of the lymphocytes and clonally rearranged T-cell...

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Published inMedicinski pregled Vol. 69; no. 11-12; pp. 376 - 378
Main Authors Zeremski, Vanja, Savic, Aleksandar, Cemerikic Martinovic, Vesna, Milosevic, Ivana, Dragicevic, Marina, El Farra, Amir
Format Journal Article
LanguageEnglish
Published Serbia 01.11.2016
Subjects
Adult
Anemia - complications
Anemia - therapy
Blood Transfusion
Cyclosporine - therapeutic use
Humans
Leukemia, Large Granular Lymphocytic - complications
Leukemia, Large Granular Lymphocytic - drug therapy
Male
Remission Induction
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Summary:A 41-year-old man presented with anemia, lymphocytosis and splenoniegaly. T-cell large granular lymphocyte leukemia was diagnosed based on lymphocytosis of T-cell large granular lymphocytes, characteristic inimunophenotype (CD)3⁺ CD8⁺, CD16⁺, CD57⁺) of the lymphocytes and clonally rearranged T-cell receptor genes. Therapy indication was transfusion-dependent anemia. Initial cyclosporine therapy and low-dose oral methotrexate failed to control anemia and lymphocytosis. Yet, a complete clinical and hematological. response (without molecuIlar remission) was achieved and sustained when cyclosporine was reintroduced into the therapy. Our case confirms that cyclosporine therapy is effective in treating T-celI large granular lymphocyte leukemia and suggests that indefinite treatment may not be needed to maintain the response.
Bibliography:ObjectType-Case Study-2
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ISSN:0025-8105
DOI:10.2298/mpns1612376z