Role of acetylcholine in gelsenicine-induced death in mice

The aim of this study was to investigate the relationship between the acetylcholine concentration in the blood and gelsenicine-induced death in mice. Kunming mice were given intraperitoneal injections of normal saline, gelsenicine or different doses of acetylcholine chloride. Atropine was given to t...

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Published inSheng li hsüeh pao Vol. 68; no. 3; p. 249
Main Authors Lai, Zhou-Yi, Wang, Hai-Bo, Lv, Rui-Ling, Tan, Qiu-Chan, Deng, Zhi-Qin, Wang, Yuan, Sun, Xiao-Xue, Wu, Jia-Bao, Zhu, Lin-Yan, Wang, Lei, Chen, Li-Xin, Ye, Wen-Cai, Wang, Li-Wei
Format Journal Article
LanguageChinese
Published China 25.06.2016
Subjects
Acetylcholine
Animals
Death
Indole Alkaloids
Mice
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Summary:The aim of this study was to investigate the relationship between the acetylcholine concentration in the blood and gelsenicine-induced death in mice. Kunming mice were given intraperitoneal injections of normal saline, gelsenicine or different doses of acetylcholine chloride. Atropine was given to the mice which received gelsenicine or medium dose acetylcholine chloride injection. The blood was sampled immediately when the mice died or survived for 20 min after injection. The acetylcholine concentration and acetylcholinesterase activity in the blood were measured by the testing kits, and the mortality was calculated and analyzed. The results showed that half lethal dose of gelsenicine (0.15 mg/kg) reduced the acetylcholinesterase activity and increased the blood acetylcholine concentration. The blood acetylcholine concentration of the dead mice in the gelsenicine group was increased to 43.0 μg/mL (from 31.1 μg/mL in the control), which was lower than that (53.9 μg/mL) of the dead mice in the medium dose acety
ISSN:0371-0874