Protection against Salmonella via immunization with recombinant lactic acid bacteria

Mucosal immunization of hens may be effective to prevent contamination of Salmonella enterica serovar Enteritidis (SE) in eggs. Lactic acid bacteria have been considered potential vaccine delivery agents because they are safe, immunogenic, and inexpensive. Our research group has been investigating t...

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Bibliographic Details
Published inNihon rinshō Vol. 70; no. 8; p. 1293
Main Author Kajikawa, Akinobu
Format Journal Article
LanguageJapanese
Published Japan 01.08.2012
Subjects
Adjuvants, Immunologic
Animals
Antigens, Bacterial - immunology
Bacterial Vaccines - immunology
Chickens
Eggs - microbiology
Food Contamination - prevention & control
Humans
Interleukin-1beta
Lactobacillus casei - genetics
Lactobacillus casei - immunology
Mice
Poultry Diseases - prevention & control
Recombination, Genetic
Salmonella enteritidis - immunology
Salmonella Infections, Animal - prevention & control
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Summary:Mucosal immunization of hens may be effective to prevent contamination of Salmonella enterica serovar Enteritidis (SE) in eggs. Lactic acid bacteria have been considered potential vaccine delivery agents because they are safe, immunogenic, and inexpensive. Our research group has been investigating the development of oral vaccines against SE using a Lactobacillus casei strain as an antigen delivery vehicle. Recombinant lactobacilli expressing SE antigens FliC and SipC have been constructed and administered to mice. Antigen specific immune responses and protective immunity were elicited after the immunization. For adjuvant delivery, IL-1beta-secreting L. casei was also engineered and its efficacies were evaluated in vitro and in vivo. This article reviews a novel approach to develop SE vaccines using recombinant lactobacilli.
ISSN:0047-1852