Expression of transcription factor SOX4 and its clinical significance in female lung cancer patients in Xuanwei area, Yunnan Province

• Published in: Zhōnghuá zhŏngliú zázhì Vol. 35; no. 3; p. 202
• Main Authors: Zhou, Yong-chun, Wang, Xi-cai, Chen, Yan, Zhang, Li-juan, Liu, Xin, Yao, Qian, Chen, Xiao-qun, Zhao, Guang-qiang, Huang, Yun-chao
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2013
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adult; Aged; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; China; Female; Follow-Up Studies; Humans; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; Proportional Hazards Models; RNA, Messenger - metabolism; SOXC Transcription Factors - genetics; SOXC Transcription Factors - metabolism; Survival Rate; Up-Regulation; China
• ISSN: 0253-3766
• DOI: 10.3760/cma.j.issn.0253-3766.2013.03.009

To investigate the expression of transcription factor SOX4 in lung cancer tissues of female patients in Xuanwei area, Yunnan Province, and explore its correlation with clinicopathological characteristics and prognosis of the female patients. Real-time PCR was applied on lung cancer specimens and their corresponding normal lung tissues from 96 female cases of Xuanwei area to assess the expression of SOX4 mRNA. Immunohistochemical staining was performed to investigate the SOX4 protein expression, and further to elucidate its correlation with clinicopathological characteristics and prognosis. The expression level of SOX4 mRNA in the cancer tissues (2.53 ± 1.65) was significantly higher than that of matched normal tissues (1.43 ± 1.14, P = 0.003). Immunohistochemical staining showed that there were 53.1% (51/96) positive expression of SOX4 protein in the cancer tissue and only 26.0% (25/96) in matched normal tissue (P < 0.001). The expression of SOX4 protein had a significant correlation with clinical stage, lymp