COMPARATIVE EXPERIMENTAL EVALUATION OF THE EFFECTIVENESS OF MODERN PROBIOTICS, PREBIOTICS, SYNBIOTICS AND METABIOTICS FOR CORRECTION OF INTESTINAL MICROBIOCENOSIS IN ANIMALS WITH ANTIBIOTIC-ASSOCIATED DYSBIOSIS

Probiotics for decades were leading in the arsenal of tools for correction of intestinal microbiocenosis. However, the response of representatives of intestinal microbiota to enteral intake of probiotics is variable, and in some individuals may be missing. Despite the fact that scientists still disa...

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Published inĖksperimental'nai͡a︡ i klinicheskai͡a︡ gastroėnterologii͡a no. 7; p. 106
Main Authors Chicherin, I Yu, Pogorelsky, I P, Lundovskikh, I A, Darmov, I V, Shabalina, M R, Podvolotsky, A N
Format Journal Article
LanguageRussian
Published Russia (Federation) 2016
Subjects
Animals
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - pharmacology
Drug Evaluation, Preclinical
Dysbiosis - chemically induced
Dysbiosis - microbiology
Dysbiosis - therapy
Gastrointestinal Microbiome - drug effects
Humans
Mice
Prebiotics - administration & dosage
Probiotics - pharmacology
Synbiotics - administration & dosage
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Summary:Probiotics for decades were leading in the arsenal of tools for correction of intestinal microbiocenosis. However, the response of representatives of intestinal microbiota to enteral intake of probiotics is variable, and in some individuals may be missing. Despite the fact that scientists still disagree on the necessity of forced settlement of normal microbiota at intestinal dysbiosis, large number of medicinal products, functional foods, dietary supplements, which efficiency is not always straightforward, is available for sale. The results of comparative experimental study of the effectiveness of 18 modern preparations for correction of intestinal microbiocenosis at antibiotic-associated dysbiosis in animals are presented. Conclusion is done on the need to evaluate efficacy and safety of tools developed for intestinal microbiota correction in animal experiments, followed by confirmation of clinical trials.
ISSN:1682-8658