Acupuncture preconditioning at "Zusanli"(ST36) and "Zhongwan"(CV12) prevents stress gastric ulcer by regulating the TLR4/MyD88/IκB signaling pathway

• Published in: Zhēncì yánjiū Vol. 46; no. 3; p. 173
• Main Authors: Li, Li, Qi, Wei, Wang, Zhao-Hui, Zhi, Ding-Ming, Jiang, Hai-Lin, Zheng, Li-Wen, Wang, Fu-Chun
• Format: Journal Article
• Language: Chinese
• Published: China 25.03.2021
• Subjects: Acupuncture Points; Acupuncture Therapy; Animals; Myeloid Differentiation Factor 88 - genetics; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Rats, Wistar; Signal Transduction; Stomach Ulcer - genetics; Stomach Ulcer - therapy; Toll-Like Receptor 4 - genetics; Oxidative stress; Stress gastric ulcer; Inflammation; Electroacupuncture
• ISSN: 1000-0607
• DOI: 10.13702/j.1000-0607.200963

To observe the effect of electroacupuncture preconditioning at "Zusanli"(ST36，Lower Confluent point) and "Zhongwan"(CV12，Front-Mu point) combination on oxidative stress and inflammation-related indicators, Toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88) and inhibitor-α of nuclear transcription factor κB (IκB-α) in serum and gastric tissue of rats with stress gastric ulcer(SGU)，so as to explore its mechanisms underlying prevention of SGU. A total of 36 Wistar rats were randomly divided into blank control, model, positive drug and He-Sea-Front-Mu point combination groups ( =9 in each group). A rat model of SGU was established by restraint water-immersion stress method. Ten days before mode-ling, rats in the He-Sea-Front-Mu point combination group received electroacupuncture （2 Hz, 0.6 mA）at ST36 and CV12 for 10 min once every other day for 10 days, and those in the positive drug group was treated by gavage of omeprazole (20 mg/kg) once every other day for 10 days. The morphology of the ga