Expression of Notch3 and hypertensive renal fibrosis

• Published in: Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban Vol. 38; no. 11; p. 1130
• Main Authors: Xu, Hui, Zhang, Jin, Zheng, Li, Zhang, Saiya, Cheng, Xiaomiao
• Format: Journal Article
• Language: Chinese
• Published: China 01.11.2013
• Subjects: Animals; Arteriosclerosis; Essential Hypertension; Fibrosis; Humans; Hypertension - metabolism; Hypertension - pathology; Kidney - pathology; Kidney Diseases - metabolism; Kidney Diseases - pathology; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Notch3; Receptors, Notch - metabolism
• ISSN: 1672-7347
• DOI: 10.3969/j.issn.1672-7347.2013.11.008

To examine the expression of notch3 in the kidneys of patients with primary hypertension and rats with spontaneous hypertension, and to explore the relationship of notch3 and hypertension renal fibrosis. Thirteen patients with primary hypertension served as a primary hypertension group (HP group), and 15 patients with kidney tumor served as a control group (CP group). The spontaneous hypertensive rats served as a primary hypertension group (SHR group, n=6), and WKY rats served as a control group (WKY group, n=6). Masson stainning was used to examine the collagen in the kidneys in the SHR group and the WKY group. Immunohistochemical staining was used to detect the levels of Notch3 in kidneys of the patients and the rats. The expression of snail mRNA in the kidneys in the SHR group and the WKY group was examined by real-time PCR. Masson staining showed much more collagen in the SHR group than that in the WKY group (P<0.05); the expression of Notch3 in the HP group was much higher than that in the CP group ( 6.7