Inhibitory effect of zoledronate sodium on periprosthetic osteolysis induced by polyethylene particles

To observe the effect and mechanisim of zoledronate sodium on periprosthetic osteolysis in rat induced by polyethylene particles. Total 30 adult male SD rats, weighting from 250 to 300 g, were selected and randomly divided into three groups: blank control group, model control group and zoledronate s...

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Bibliographic Details
Published inZhongguo gu shang Vol. 28; no. 10; p. 936
Main Authors Wu, Feng-qing, Ye, Jian, Wu, Lian-guo
Format Journal Article
LanguageChinese
Published China 01.10.2015
Subjects
Animals
Bone Density - drug effects
Collagen Type I - analysis
Cytokines - analysis
Diphosphonates - therapeutic use
Imidazoles - therapeutic use
Joint Prosthesis
Male
Osteolysis - drug therapy
Peptides - analysis
Polyethylene - pharmacology
Rats
Rats, Sprague-Dawley
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Summary:To observe the effect and mechanisim of zoledronate sodium on periprosthetic osteolysis in rat induced by polyethylene particles. Total 30 adult male SD rats, weighting from 250 to 300 g, were selected and randomly divided into three groups: blank control group, model control group and zoledronate sodium group respectively, 10 animals for each group. No treatment was performed in the blank control group. In model control group and zoledronate sodium group, the modle of periprosthetic osteolysis in rats were made by implanting polyethylene particles and titanium rods into their right femurs. After operation, rats in zoledronate sodium group were administered with zoledronate sodium (0.1 mg/kg each week) through subcutaneous injection for 8 weeks, then the blood was obtained and all experimental animals were sacrificed to get the right femur specimens. The femur BMD, IL-1β, IL-6, TNF-α, serum TRACP5b and CTX-I were detected. Compared with the model control group, the femur BMD was increased, while IL-1β, IL-6 a
ISSN:1003-0034