Amyloid β protein suppresses hippocampal theta rhythm and induces behavioral disinhibition and spatial memory deficit in rats

Hippocampal neuronal network oscillation is closely related to the memory, anxiety and behavioral inhibition of mammalian. The cognitive decline and behavioral disinhibition in the patients with Alzheimer's disease (AD) may be relevant to amyloid β protein (Aβ)-induced impairment in hippocampal...

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Bibliographic Details
Published inSheng li hsüeh pao Vol. 66; no. 2; p. 97
Main Authors Yue, Xing-Hua, Liu, Xiao-Jie, Wu, Mei-Na, Chen, Jin-Yuan, Qi, Jin-Shun
Format Journal Article
LanguageChinese
Published China 25.04.2014
Subjects
Amyloid beta-Peptides - adverse effects
Animals
Down-Regulation
Hippocampus - physiopathology
Maze Learning
Neuronal Plasticity
Peptide Fragments - adverse effects
Rats
Spatial Memory
Theta Rhythm
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Summary:Hippocampal neuronal network oscillation is closely related to the memory, anxiety and behavioral inhibition of mammalian. The cognitive decline and behavioral disinhibition in the patients with Alzheimer's disease (AD) may be relevant to amyloid β protein (Aβ)-induced impairment in hippocampal neuronal cooperative activity. However, it is not well known whether intrahippocampal injection of Aβ could induce behavioral disinhibition and neuronal network disorder, as well as cognition decline in animals. In the present study, we observed the effects of intracerebral injection of Aβ(1-42) on the spatial memory and behavioral inhibition of rats by using Morris water maze and elevated plus-maze tests. Further, we analyzed hippocampal theta rhythm by recording hippocampal local field potential. The results showed that: (1) bilateral hippocampal injection of Aβ(1-42) reduced the anxious behavior of rats, with a significant behavioral disinhibition in the elevated plus-maze test, representing as an increase in the me
ISSN:0371-0874