Meta-analysis of the diagnostic efficacy of heparin binding protein in adult sepsis

To evaluate the accuracy of heparin binding protein (HBP) in the diagnosis of adult sepsis by meta-analysis. The retrospective, randomized controlled and prospective researches on the diagnosis of adult sepsis using HBP were reviewed by searching VIP network, China National Knowledge Infrastructure...

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Published inZhonghua wei zhong bing ji jiu yi xue Vol. 31; no. 11; p. 1330
Main Authors Chen, Shidong, Zhang, Cuixia, Hong, Guolin, Wang, Qianming, Lian, Mingjian
Format Journal Article
LanguageChinese
Published China 01.11.2019
Subjects
Adult
Carrier Proteins
China
Heparin
Humans
Prospective Studies
Retrospective Studies
Sensitivity and Specificity
Sepsis - diagnosis
China
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Summary:To evaluate the accuracy of heparin binding protein (HBP) in the diagnosis of adult sepsis by meta-analysis. The retrospective, randomized controlled and prospective researches on the diagnosis of adult sepsis using HBP were reviewed by searching VIP network, China National Knowledge Infrastructure (CNKI), Wanfang database, PubMed, Embase and Web of Science from foundation to August 2018. The researches were selected according to inclusion and exclusion criteria, and QUADAS was used to evaluate the quality of eligible studies. Metadisc 14.0 was used to analyze the threshold effect, pool the estimation and do Meta regression analysis. Publication bias was assessed using Stata 12.0 with Deeks funnel plot. A total of 728 related literatures were searched and 14 studies were enrolled in this study with a total of 2 023 subjects, with 1 120 in sepsis group and 903 in non-sepsis control group (795 patients with non-sepsis and 108 healthy volunteers). The total score of literature quality was 14-23, indicating that
ISSN:2095-4352
DOI:10.3760/cma.j.issn.2095-4352.2019.11.004