Function of NOD-like receptor protein 1 inflammasome in traumatic central nervous system injury

NOD-like receptor protein 1 (NLRP1) inflammasome plays an important role in the innate immune response of human body. It can promote the activation of cysteinyl aspartate specific proteinases(Caspases), further activate interleukin-18 and interleukin-1 β, and mediate pyroptosis. NlRP1 inflammasome p...

Full description

Saved in:
Bibliographic Details
Published inZhongguo gu shang Vol. 34; no. 11; p. 1058
Main Authors Li, Ya-Feng, Yi, Ping, Wang, Yan-Lei, Wu, Xin-Jie, Yang, Feng, Ma, Hao-Ning, Tan, Ming-Sheng
Format Journal Article
LanguageChinese
Published China 25.07.2021
Subjects
Central Nervous System - injuries
Humans
Inflammasomes
NLR Proteins - metabolism
Pyroptosis
Review
NOD like receptor protein 1
Traumatic central nervous system injury
Online AccessGet more information

Cover

More Information
Summary:NOD-like receptor protein 1 (NLRP1) inflammasome plays an important role in the innate immune response of human body. It can promote the activation of cysteinyl aspartate specific proteinases(Caspases), further activate interleukin-18 and interleukin-1 β, and mediate pyroptosis. NlRP1 inflammasome plays a role in traumatic central nervous system injury. In this study, the structure of NLRP1 inflammasome, the activation of NLRP1 inflammasome in traumatic central nervous system injury and the treatment with NLRP1 inflammasome as a target are reviewed.
ISSN:1003-0034
DOI:10.12200/j.issn.1003-0034.2021.11.014