Morphologic diagnosis and onset characteristics of acute leukemia: a retrospective analysis of 233 cases in 10 years

The objective of this study was to evaluate the value of morphologic diagnosis for acute leukemia (AL), to explore the relation of morphologic diagnosis with immunology, cytogenetics and molecular biology diagnosis of AL and to analyze the onset characteristics of AL in 10 years. The samples of bone...

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Published inZhongguo shi yan xue ye xue za zhi Vol. 20; no. 4; p. 823
Main Authors Liu, Yi, Huang, You-Zhang, Gong, Li-Zhong, Cen, Jian, Wang, Li-Xin, Xiang, Dan, Ma, Wei-Na, Tang, Xiang-Feng, Wu, Nan-Hai, Gong, Xiao-Jun, Wang, Kai, Yin, Wen-Jie, Zhao, De-Feng, Liu, Xiao-Peng, Hu, Xiao-Shan, Shen, Jian-Liang
Format Journal Article
LanguageChinese
Published China 01.08.2012
Subjects
Acute Disease
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Cytogenetic Analysis
Female
Humans
Infant
Leukemia - diagnosis
Leukemia - pathology
Male
Middle Aged
Molecular Biology
Retrospective Studies
Young Adult
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Summary:The objective of this study was to evaluate the value of morphologic diagnosis for acute leukemia (AL), to explore the relation of morphologic diagnosis with immunology, cytogenetics and molecular biology diagnosis of AL and to analyze the onset characteristics of AL in 10 years. The samples of bone marrow and peripheral blood from 233 newly diagnosed cases of AL were collected during 2001-2011 years; the morphologic examination and immunologic, cytogenetic and molecular biologic examination (ICM) were carried out, the consistency of morphologic diagnosis with ICM diagnosis was compared, the onset characteristics of AL was analyzed. The results showed that: (1) the consistent rate of immunology, cytogenetics, molecular biology diagnosis with morphologic diagnosis was 84.3%. The order of consistent rat was AUL, M0 < M1 < HAL < M4 < M2 < M3 < M5 < ALL < M6, M7, AP; (2) Misdiagnosis always occurred among AUL, M0, M1, ALL and HAL or among M2a, M3v, M4 and M5. (3) In 233 cases, the highest ratio of blast was obser
ISSN:1009-2137