Expression Level of S100A6 mRNA in MM and Its Clinical Significance

To investigate the expression level of S100A6 mRNA in MM and to its clinical significance, and to evaluate its significance. The expression level of S100A6 mRNA in MM patients was determined by real time quantitative PCR(RQ-PCR), and its relationship with the clinical features and outcomes of patien...

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Published inZhongguo shi yan xue ye xue za zhi Vol. 24; no. 5; p. 1466
Main Authors Bao, Hong-Yu, Wang, Jian-Nin, Meng, Qing-Qi, Song, Min, Fu, Xing-Cai, Hou, Yan-Qiu, Zhang, Liu-Bo, Jiang, Su-Yu
Format Journal Article
LanguageChinese
Published China 01.10.2016
Subjects
Cell Cycle Proteins
Humans
Multiple Myeloma
Real-Time Polymerase Chain Reaction
RNA, Messenger
S100 Calcium Binding Protein A6
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Summary:To investigate the expression level of S100A6 mRNA in MM and to its clinical significance, and to evaluate its significance. The expression level of S100A6 mRNA in MM patients was determined by real time quantitative PCR(RQ-PCR), and its relationship with the clinical features and outcomes of patients was analyzed by statistic method. S100A6 mRNA was detected in 20 MM patients. Compared with normal persons, the S100A6 mRNA expression in MM patients was higher. In different groups, the S100A6 mRNA expression in MM patients of 3 stages was higer than that in patients of 1 and 2 stages. MM patients with higher S100A6 mRNA expression had poor prognosis and higer extramedullary metastasis rate. The high expression of S100A6 mRNA is associated with poor prognosis and may be a prognostic molecular marker of MM.
ISSN:1009-2137
DOI:10.7534/j.issn.1009-2137.2016.05.033