In vitro and in vivo evaluation of total flavones of Hippophae rhamnoides self-microemulsifying drug delivery system

• Published in: Yao hsüeh hsüeh pao Vol. 47; no. 8; p. 1055
• Main Authors: Li, Gui-ling, Fan, Ya-ting, Zhang, Yan-hui, Li, Yan-fang, Li, Xin-ru, Liu, Yan, Li, Mei
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2012
• Subjects: Administration, Oral; Animals; Biological Availability; Drug Carriers; Drug Delivery Systems; Emulsions; Flavones - administration & dosage; Flavones - isolation & purification; Flavones - pharmacokinetics; Fruit - chemistry; Hippophae - chemistry; Intestinal Absorption; Male; Particle Size; Plant Leaves - chemistry; Plants, Medicinal - chemistry; Random Allocation; Rats; Rats, Sprague-Dawley

The goal of the study is to evaluate the self-microemulsifying drug delivery system (SMEDDS) which enhances the oral bioavailability of the poorly water-soluble drug, total flavones of Hippophae rhamnoides (TFH). It is orally administered for the protection of human cardiovascular system. Self-micro...