In vitro and in vivo evaluation of total flavones of Hippophae rhamnoides self-microemulsifying drug delivery system
The goal of the study is to evaluate the self-microemulsifying drug delivery system (SMEDDS) which enhances the oral bioavailability of the poorly water-soluble drug, total flavones of Hippophae rhamnoides (TFH). It is orally administered for the protection of human cardiovascular system. Self-micro...
Saved in:
Published in | Yao hsüeh hsüeh pao Vol. 47; no. 8; p. 1055 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | Chinese |
Published |
China
01.08.2012
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Summary: | The goal of the study is to evaluate the self-microemulsifying drug delivery system (SMEDDS) which enhances the oral bioavailability of the poorly water-soluble drug, total flavones of Hippophae rhamnoides (TFH). It is orally administered for the protection of human cardiovascular system. Self-microemulsifying time, particle size, polydispersity index (PDI), morphological characterization, in vitro dispersity, stability, in situ intestinal absorption and relative bioavailability were investigated in detail. The TFH-SMEDDS rapidly formed fine oil-in-water microemulsions with 0.1 mol x L(-1) hydrochloride solution, with average size of which was less than 40 nm, PDI was below 0.2, and the particles of which were observed round-shaped under transmission electron microscope. Almost 90% of TFH (expressed with quercetin) was released from SMEDDS within 20 min, which was remarkably higher than that from common capsules. The stability test showed the TFH-SMEDDS maintained stable in 6 months under accelerated conditio |
---|---|
ISSN: | 0513-4870 |