In vitro and in vivo evaluation of total flavones of Hippophae rhamnoides self-microemulsifying drug delivery system

The goal of the study is to evaluate the self-microemulsifying drug delivery system (SMEDDS) which enhances the oral bioavailability of the poorly water-soluble drug, total flavones of Hippophae rhamnoides (TFH). It is orally administered for the protection of human cardiovascular system. Self-micro...

Full description

Saved in:
Bibliographic Details
Published inYao hsüeh hsüeh pao Vol. 47; no. 8; p. 1055
Main Authors Li, Gui-ling, Fan, Ya-ting, Zhang, Yan-hui, Li, Yan-fang, Li, Xin-ru, Liu, Yan, Li, Mei
Format Journal Article
LanguageChinese
Published China 01.08.2012
Subjects
Administration, Oral
Animals
Biological Availability
Drug Carriers
Drug Delivery Systems
Emulsions
Flavones - administration & dosage
Flavones - isolation & purification
Flavones - pharmacokinetics
Fruit - chemistry
Hippophae - chemistry
Intestinal Absorption
Male
Particle Size
Plant Leaves - chemistry
Plants, Medicinal - chemistry
Random Allocation
Rats
Rats, Sprague-Dawley
Online AccessGet more information

Cover

More Information
Summary:The goal of the study is to evaluate the self-microemulsifying drug delivery system (SMEDDS) which enhances the oral bioavailability of the poorly water-soluble drug, total flavones of Hippophae rhamnoides (TFH). It is orally administered for the protection of human cardiovascular system. Self-microemulsifying time, particle size, polydispersity index (PDI), morphological characterization, in vitro dispersity, stability, in situ intestinal absorption and relative bioavailability were investigated in detail. The TFH-SMEDDS rapidly formed fine oil-in-water microemulsions with 0.1 mol x L(-1) hydrochloride solution, with average size of which was less than 40 nm, PDI was below 0.2, and the particles of which were observed round-shaped under transmission electron microscope. Almost 90% of TFH (expressed with quercetin) was released from SMEDDS within 20 min, which was remarkably higher than that from common capsules. The stability test showed the TFH-SMEDDS maintained stable in 6 months under accelerated conditio
ISSN:0513-4870