Combination with different anticholinergic eyedrops for the treatment of children myopia

• Published in: Zhong hua yi xue za zhi Vol. 99; no. 24; p. 1859
• Main Authors: Han, W T, Rong, A, Xu, W
• Format: Journal Article
• Language: Chinese
• Published: China 25.06.2019
• Subjects: Racanisodamine; Atropine; Cholinergic antagonists; Adolescent; Myopia
• ISSN: 0376-2491
• DOI: 10.3760/cma.j.issn.0376-2491.2019.24.005

To observe the efficacy and feasibility of a new therapy using a combination of different anticholinergic eyedrops in controlling myopia progression and axial prolongation in adolescents. Between July 2013 and June 2014, a total of 150 myopia adolescents aged 6-12 years were recruited at the clinic of Tongji Hospital in Shanghai. Participants were assigned in a 1∶2∶2 ratio to placebo group (no medication), combined treatment group (0.5% racanisodamine eyedrops were used twice a day during semesters, 1% atropine eyedrops were used before sleep during vacation) and atropine group (1% atropine eyedrops were used before sleep everyday). All subjects wore glasses. Visual acuity, best corrected visual acuity, cycloplegic refraction, corneal curvature, axial length, intraocular pressure, fundus and adverse events were recorded every 6 months during follow-up for 24 months. At baseline, there was no significant difference in age,equivalent spherical mirror number and axial length among the three groups (all 0.05). At