Preparation and property study of doxorubicin loaded microspheres

To prepare doxorubicin-loaded polyvinylalcohol-acrylic acid (PVA-AA) microspheres and evaluate properties of this chemoembolic agent. PVA-AA microspheres were synthesized by inverse suspension polymerization method and then verified by infrared spectroscopy. drug loading (DL) and entrapment efficien...

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Published inBeijing da xue xue bao. Journal of Peking University. Yi xue ban Vol. 46; no. 4; p. 629
Main Authors Sa, Er-a, Lu, Xiao-jing, Cui, Dai-chao, Guan, Hai-tao, Lv, Tian-shi, Zhang, Shei-sheng, Yan, Zi-guang, Song, Li, Zou, Ying-hua, Fan, Tian-yuan
Format Journal Article
LanguageChinese
Published China 18.08.2014
Subjects
Acrylates
Animals
Doxorubicin - chemistry
Drug Carriers - chemistry
Elasticity
Embolization, Therapeutic
Microspheres
Polyvinyl Alcohol
Rabbits
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Summary:To prepare doxorubicin-loaded polyvinylalcohol-acrylic acid (PVA-AA) microspheres and evaluate properties of this chemoembolic agent. PVA-AA microspheres were synthesized by inverse suspension polymerization method and then verified by infrared spectroscopy. drug loading (DL) and entrapment efficiency (EE%) were measured after doxorubicinwas loaded on PVA-AA microspheres. Their morphology and elasticity were investigated by optical microscope, environmental scanning electron microscope and texture analyzer, respectively. T-cell apparatus was used to evaluate the in vitro release behavior of doxorubicin-loaded microspheres.The external carotid of the rabbit was chosen as an embolization site to evaluate the in vivo embolic property of the microspheres. PVA-AA microspheres, which were transparent spheres,turned into red spheres after doxorubicin loading. DL of the microspheres was (20.56 ± 0.69)g/L and (23.25 ± 0.27) g/L,and EE% was 82.22% ± 2.76% and 93.00% ± 1.06% within 20 min and 6 h, respectively. The in v
ISSN:1671-167X