Characteristics of complete genome of pandemic A/H1N1/2009 influenza virus isolated in Fujian Province, China

• Published in: Bingdu xuebao Vol. 30; no. 1; p. 37
• Main Authors: Xie, Jian-Feng, Shen, Xiao-Na, Wang, Mei-Ai, Yang, Shi-Qin, Huang, Meng, Zhang, Yan-Hua, Xiu, Wen-Qiong, Weng, Yu-Wei, Yan, Yan-Sheng, Zheng, Kui-Cheng
• Format: Journal Article
• Language: Chinese
• Published: China 01.01.2014
• Subjects: Antiviral Agents - pharmacology; China - epidemiology; Drug Resistance, Viral - genetics; Genome, Viral - genetics; Genomics; Humans; Influenza A Virus, H1N1 Subtype - drug effects; Influenza A Virus, H1N1 Subtype - genetics; Influenza A Virus, H1N1 Subtype - immunology; Influenza A Virus, H1N1 Subtype - physiology; Influenza, Human - epidemiology; Influenza, Human - prevention & control; Pandemics - prevention & control; Viral Vaccines - immunology; China
• ISSN: 1000-8721

This study aims to investigate the characteristics of genomic variation of pandemic A/H1N1/2009 influenza virus isolated in Fujian Province, China. Complete genome sequence analysis was performed on 14 strains of pandemic A/H1N1/2009 influenza virus isolated from Fujian during 2009-2012. All virus strains were typical low-pathogenic influenza viruses, with resistance to amantadine and sensitivity to neuraminidase inhibitors. Eight genome fragments of all strains were closely related to those of A/California/07/2009 (H1N1) vaccine strain, with > or = 98.2% homology. Compared with the vaccine strain, the influenza strains from Fujian had relatively large variation, and variation was identified at 11 amino acid sites of the HA gene of A/Fujiangulou/SWL1155/2012 strain, including 4 sites (H138R, L161I, S185T, and S203T) involved inthree antigen determinants (Ca, Sa, and Sb). In conclusion, the influenza vaccine has a satisfactory protective effect on Fujian population, but the influenza strains from Fujian in 201