Studies on resistance of Schistosoma to praziquantel XVII Biological characteristics of praziquantel-resistant isolates of Schistosoma japonicum in mice

To investigate the biological characteristics of the praziquantel-resistant isolate of in mice, so as to explore the pathogenicity to definitive hosts and transmission intensity of the praziquantel-resistant isolate of . Mice were infected with the cercariae released from two praziquantel-resistant...

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Published inZhongguo xue xi chong bing fang zhi za zhi Vol. 29; no. 6; p. 683
Main Authors Ke, Qian, You-Sheng, Liang, Wei, Wang, Guo-Li, Qu, Hong-Jun, Li, Zhen-Kun, Yang, Zheng-Yang, Zhao, Yuntian, Xing, Jian-Rong, Dai
Format Journal Article
LanguageChinese
Published China 26.12.2017
Subjects
Biological characteristics
Mouse
Drug resistance
Schistosoma japonicum
Praziquantel
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Summary:To investigate the biological characteristics of the praziquantel-resistant isolate of in mice, so as to explore the pathogenicity to definitive hosts and transmission intensity of the praziquantel-resistant isolate of . Mice were infected with the cercariae released from two praziquantel-resistant isolates and two praziquantel-susceptible isolates of . The mouse- snail-mouse cycle was established and maintained in the laboratory. The prepatent period of parasite eggs, egg production, egg distribution in mice, parasite susceptibility to mice and egg size were investigated in each parasite isolate. The prepatent period of parasite eggs, egg counts in mouse feces, adult worms recovered from each mouse, egg counts in mouse tissues, egg counts in the mouse liver, and egg counts in intestine tissues were 36.1 d and 36.8 d ( = 0.907, = 0.372), 14.6 / 100 mg and 21.2 / 100 mg ( = 2.946, = 0.007), 20.5 and 25.1 worms per mouse ( = 2.128, = 0.042), 31 303 and 38 594 per paired adult worm ( = 2.185, = 0.04), 14 810 and
ISSN:1005-6661
DOI:10.16250/j.32.1374.2017102