Results of the Russian EKSPERT program: post-marketing supervision over efficacy and influence of the preparation Ekvator on quality of life at out-patients with arterial hypertension

• Published in: Kardiologiia Vol. 54; no. 3; p. 15
• Main Authors: Glezer, M G, Vygodin, V A, Avakian, A A, Prokof'eva, E B
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2014
• Subjects: Aged; Ambulatory Care - methods; Ambulatory Care - psychology; Ambulatory Care - statistics & numerical data; Amlodipine - administration & dosage; Amlodipine - adverse effects; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - adverse effects; Blood Pressure - drug effects; Blood Pressure Monitoring, Ambulatory; Comorbidity; Drug Combinations; Drug Monitoring - methods; Drug Substitution - methods; Drug-Related Side Effects and Adverse Reactions - epidemiology; Female; Humans; Hypertension - diagnosis; Hypertension - drug therapy; Hypertension - epidemiology; Hypertension - psychology; Lisinopril - administration & dosage; Lisinopril - adverse effects; Male; Middle Aged; Product Surveillance, Postmarketing; Program Evaluation; Quality of Life; Risk Factors; Russia - epidemiology; Treatment Outcome; Russia
• ISSN: 0022-9040
• DOI: 10.18565/cardio.2014.3.15-22

Results of an open multicenter prospective postmarketing observational program EKSPERT (post-marketing surveillance of the effectiveness and impact of the EKVATOR treatment on quality of life in patients with arterial hypertension in ambulatory practice). Observation of 10 000 patients conducted in 300 medical center in various regions of the Russian Federation in 1005 doctors. Selected for the final analysis 4954 registration cards. It is shown that in patients with initially insufficient effective antihypertensive treatment has a large number of risk factors: men older than 55 years--56.5%, women older than 65 years--27.8%, unfavorable family history of arterial hypertension (AH)--87.9%, diabetes mellitus (DM)--13.4%, smoking--of patients 18.6%, obesity--35%, angina--35.59%, heart failure--41.3% with a history of myocardial infarction--10.9%, stroke--4.5%, renal disease--11.8%, hypercholesterolemia > 5.0 mmol/l--76.7%. Initially drug antihypertensive treatment was performed in 76.6% of patients, while 43.9% were treated regularly. Prior studies angiotensin converting enzyme inhibitors (ACE) afforded 60.56%, sartans--11% of patients, beta-blockers--41.9%, duretics--41.46%, calcium antagonists used in 21.42% of the patients. After the cancellation of previously used other ACE inhibitors, calcium antagonists and sartans patients were switched to therapy with the EKVATOR (amlodipine and lisinopril). Intensity reduction in systolic and diastolic blood pressure (SBP and DBP) did not depend on sex of the patients, the presence of angina, diabetes. Greater reduction in blood pressure in hypertensive duration more than 5 years, in the presence of congestive heart failure due to more frequent initiation of therapy with full-dose combination (amlodipine 10 mg and lisinopril 20 mg). After 1 months of starting therapy changes uorvney target blood pressure (< 140 and 90 mmHg) reached 51.5% of patients. Target SBP reached 59.7% of patients, the target level of DBP--69.4%. It is important that the majority of patients crossed over lowti graduation SBP and DBP and significantly improved their quality of life assessment. Incidence of adverse events was low--1.5% of them are the most common were swelling in the legs, headache, dizziness, and dry cough. Replacing the previous therapy different ACE inhibitors, sartans and calcium antagonists to the fixed combination amlodipine and lisinopril) (drug EKVATOR), leads to a rapid, pronounced, and safe reduction of BP and improve health in the majority of patients with previously uncorrected BP.