Effect of Bifidobacterium on the immunity in BALB/c mice

We studied the system immunofuctions of two Bifidobacterium strains isolated from food. There were 10 SPF BALB/c mice in each group. The control group was given only sterile skim milk. The positive control group was given sterile skim milk containing commercial strain BB-12. The treatment group was...

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Bibliographic Details
Published inWei sheng wu hsüeh pao Vol. 55; no. 4; p. 484
Main Authors Fan, Jinbo, Hou, Yu, Zhou, Suzhen, Cai, Xitong
Format Journal Article
LanguageChinese
Published China 04.04.2015
Subjects
Animals
Bifidobacterium - immunology
Female
Humans
Immunity - drug effects
Killer Cells, Natural - drug effects
Killer Cells, Natural - immunology
Macrophages - drug effects
Macrophages - immunology
Mice
Mice, Inbred BALB C
Phagocytosis - drug effects
Probiotics - administration & dosage
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Summary:We studied the system immunofuctions of two Bifidobacterium strains isolated from food. There were 10 SPF BALB/c mice in each group. The control group was given only sterile skim milk. The positive control group was given sterile skim milk containing commercial strain BB-12. The treatment group was given sterile skim milk containing different dosages of B. adolescentis BB-2 or B. longum BB-3. The immune parameters including cellular immunity (delayed-type hypersensitivity [DTH], splenic lymphocyte proliferation and natural killer [NK] cell activity), humoral immunity (serum hemolytic activity in immunized animals), and nonspecific immunity (peritoneal macrophages phagocytsis) were measured. Ingestion of B. adolescentis BB-2 or B. longum BB-3 could increase the DTH response. Macrophage phagocytsis was also enhanced, while activities of the NK cells and levels of the serum hemolysin were also significantly higher than that in the control group. There was a significant increase in splenic lymphocyte proliferatio
ISSN:0001-6209