Clinical Characteristics and Prognosis of MLL Rearranged Childhood Acute Lymphocyte Leukemia

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 31; no. 4; p. 973
• Main Authors: Li, Mei, Zheng, Yong-Zhi, Li, Jian, LE, Shao-Hua, Zheng, Hao, Chen, Zai-Sheng, Weng, Kai-Zhi, Zhuang, Shu-Quan, Wu, Xing-Guo, Wen, Hong
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2023
• Subjects: rearranged; acute lymphoblastic leukemia; prognosis; child
• ISSN: 1009-2137
• DOI: 10.19746/j.cnki.issn.1009-2137.2023.04.007

AbstractObjective: To investigate the clinical characteristics and prognostic factors in childhood acute lymphoblastic leukemia with gene-rearrangement-positive ( -r ALL). The clinical data of 1 414 newly diagnosed children with ALL admitted to five hospital in Fujian province from April 2011 to December 2020 were retrospectively analyzed. The clinical characteristics and efficacy of -r and -r subgroup were compared. The prognostic factors of -r ALL were analyzed by COX regression model. Among all children with ALL, the proportion of patients aged less than 1 year old was 1.8%, and the detection rate of MLL-r was 3.4% (48/1 414). The positive detection rate of -r in the age groups <1 year old, and ≥1 year old and ≤14 years old was 38.5% (10/26) and 2.7 (38/1 388), respectively, the difference was statistically significant ( <0.000). Compared with -r group, the -r group had a higher proportion of patients with age <1 year, white blood cell (WBC) count ≥50×10 /L, combined central nervous system leukemia (CNSL)