Analysis of Related Factors of Survival and Prognosis in Patients With High-risk Refractory Lymphoma Treated with Auto-PBHSCT

To analyze the factors affecting survival and prognosis of patients with high-risk refractory lymphoma treated with autologous peripheral blood hematopoietic stem cell transplantation (auto-PBHSCT). A total of 96 cases of high-risk refractory lymphoma received auto-PBHSCT were selected. The total su...

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Published inZhongguo shi yan xue ye xue za zhi Vol. 26; no. 3; p. 784
Main Authors Jiang, Li, Zhu, Zun-Min
Format Journal Article
LanguageChinese
Published China 01.06.2018
Subjects
Antineoplastic Combined Chemotherapy Protocols
Hematopoietic Stem Cell Transplantation
Humans
Lymphoma
Prognosis
Remission Induction
Retrospective Studies
Transplantation, Autologous
Treatment Outcome
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Summary:To analyze the factors affecting survival and prognosis of patients with high-risk refractory lymphoma treated with autologous peripheral blood hematopoietic stem cell transplantation (auto-PBHSCT). A total of 96 cases of high-risk refractory lymphoma received auto-PBHSCT were selected. The total survival rate after the treatment was analyzed by using Kaplan-Meier curve and long rank test, and the prognosis-related factors were analyzed by univariate analysis and COX regression analysis. The median survival time of 96 patients was 30.67 months, and the overall survival rate of 3 and 5 years after treatment was 81.25% and 71.88% respectively. Univariate analysis showed that the patients with high lactate dehydrogenase(LDH) level (>245 U/L), 3-5 scores of international prognostic index(IPI), hepatitis B virus (HBV) infection, high expression of Ki-67 (≥65%) and bone marrow infiltration had lower survival rate (P<0.05). COX regression analysis showed that the complete remission wasn't reached before auto-PBHSCT
ISSN:1009-2137
DOI:10.7534/j.issn.1009-2137.2018.03.025