Electroacupuncture improves long-term survival of myocardial infarction mice by promoting myocardial angiogenesis and inhibiting ventricular remodeling

• Published in: Zhēncì yánjiū Vol. 47; no. 3; p. 189
• Main Authors: Zhang, Jiao-Jiao, Xie, Chen-Long, Yong, Yue, Chi, Hao, Lu, Li-Yue, Zou, Ying-Hua, Ruan, Wen-Qing, Song, Jian-Gang
• Format: Journal Article
• Language: Chinese
• Published: China 25.03.2022
• Subjects: Animals; Electroacupuncture; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction - genetics; Myocardial Infarction - therapy; Myocytes, Cardiac - metabolism; Stroke Volume; Vascular Endothelial Growth Factor A - genetics; Ventricular Function, Left; Ventricular Remodeling; Heart failure; Myocardial infarction; Angiogenesis; Ventricular remodeling; Electroacupuncture
• ISSN: 1000-0607
• DOI: 10.13702/j.1000-0607.20210971

To investigate the mechanism of electroacupuncture (EA) in improving the long-term survival rate of mice after myocardial infarction by promoting angiogenesis and inhibiting ventricular remodeling. A total of 102 male C57BL/6 mice were randomly divided into sham operation, model and EA groups ( =34 /group). The myocardial infarction model was established by permanent ligation of the anterior descending branch of the left coronary artery. Beginning from the 3rd day after ligation, EA (2 Hz/20 Hz) was applied to bilateral "Neiguan" (PC6) and "Ximen" (PC4) for 30 min, once a day for 28 days. The survival rate in 140 d was recorded and the left ventricular ejection fraction (EF) calculated by using echocardiography after the treatment. The left cardiac ventricular tissue was cut into sections to be stained with Masson's trichrome, wheat germ agglutinin (WGA) or α-smooth muscle actin (α-SMA) immunohistochemistry method, followed by measuring the collagen area in the marginal region of myocardial infarction and cal