Mechanism of electroacupuncture on "Zusanli (ST 36)" for chemotherapy-induced peripheral neuropathy

• Published in: Zhōngguó zhēnjiǔ Vol. 36; no. 5; p. 512
• Main Authors: Sui, Minghong, Lessans, Sherrie, Yan, Tiebin, Cao, Dongyuan, Lao, Lixing, Dorsey, Susag G
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2016
• Subjects: Acupuncture Points; Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Electroacupuncture; Humans; Interleukin-1beta - genetics; Interleukin-1beta - metabolism; Male; Mice; Mice, Inbred C57BL; Neoplasms - drug therapy; Peripheral Nervous System Diseases - etiology; Peripheral Nervous System Diseases - genetics; Peripheral Nervous System Diseases - metabolism; Peripheral Nervous System Diseases - therapy; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism
• ISSN: 0255-2930

To observe the effects and duration of electroacupuncture on the mechanical pain threshold induced by paclitaxel and explore its analgesic mechanism. Sixty-four C57BL/6J male mice were randomly divided into 4 groups, a normal+sham EA group, a normal+EA group, a medicine+sham EA(Med+ sham EA) group, a medicine + EA (Med + EA) group, 16 cases in each group. The model of chemotherapy-induced peripheral neuropathy was established with paclitaxel intraperitoneal injection on the 1st, 3rd, 5th, 7th day in the Med + sham EA group and the Med + EA group. EA of 30 min was used on bilateral "Zusanli (ST 36)" on the 9th, 11th, 13th, 16th, 18th, 20th, 23rd, 25th, 27th, 30th day in the EA groups, 2 Hz/100 Hz and 1~ 1.5 mA. Acupuncture was applied on the same acupoint at the same times in the sham EA groups. Mechanical pain thresholds were tested by VonFrey before and after model establishment, namely on the 8th, 14th; 21st and, 28th day. The heart blood of 8 mice was drawn quickly to collect serum in every group on the 31