Elevated serum leptin levels in nonobese patients with psoriasis

Leptin, an adipocyte-derived hormone, has been shown to have several immunological effects similar to those of proinflammatory cytokines. The relationship between serum leptin, psoriasis, and obesity is still conflicted, and very few studies have investigated its role in skin diseases other than pso...

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Published inJournal of drugs in dermatology Vol. 12; no. 2; p. e25
Main Authors Aly, Dalia G, Abdallah, Ihab Y, Hanafy, Noha S, Elsaie, Mohamed L, Hafiz, Neveen A A
Format Journal Article
LanguageEnglish
Published United States 01.02.2013
Subjects
Adult
Aged
Body Mass Index
Body Weight
Enzyme-Linked Immunosorbent Assay
Female
Humans
Leptin - blood
Male
Middle Aged
Obesity - complications
Psoriasis - blood
Psoriasis - pathology
Severity of Illness Index
Skin - pathology
Skin Diseases - blood
Young Adult
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Summary:Leptin, an adipocyte-derived hormone, has been shown to have several immunological effects similar to those of proinflammatory cytokines. The relationship between serum leptin, psoriasis, and obesity is still conflicted, and very few studies have investigated its role in skin diseases other than psoriasis. To evaluate the possible relationship between serum leptin in nonobese patients with psoriasis and other randomly selected skin diseases. Eighty subjects (40 patients with psoriasis, 20 patients with other randomly selected skin diseases, and 20 healthy controls) were included in the study. Fasting serum leptin levels of the study groups were examined by sandwich enzyme-linked immunosorbent assay. Elevated serum leptin levels were detected in both nonobese patients with psoriasis (P=.004) and those with other randomly selected skin diseases (P=.05). Leptin levels failed to correlate to the Psoriasis Area and Severity Index score of psoriatic patients. Both sexes demonstrated comparable levels of serum leptin in psoriatic patients, while female patients suffering from other skin diseases showed higher levels of serum leptin than did males of the same group. Leptin may play a role in the immunopathogenesis of psoriasis and other skin diseases, even in the absence of obesity as a cofactor.
ISSN:1545-9616