Effect of four kinds of drinking water on hepatic and renal function and zinc and iron concentrations of different organs in mice

To explore the effect of different drinking water on hepatic and renal function and zinc and iron concentrations of different organs in mice. Zinc and iron concentrations were measured in pure water, tap water, mineral water and filtered tap-water, respectively. 80 ICR mice (half male and half femal...

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Published inWei sheng yan jiu Vol. 44; no. 5; p. 802
Main Authors Chen, Ronghe, Huang, Jing, Wang, Jing, Li, Xusangni, Zhang, Tongnian, Ruan, Guohong
Format Journal Article
LanguageChinese
Published China 01.09.2015
Subjects
Animals
Drinking Water
Female
Iron - metabolism
Kidney - physiology
Liver - physiology
Male
Mice
Mice, Inbred ICR
Zinc - metabolism
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Summary:To explore the effect of different drinking water on hepatic and renal function and zinc and iron concentrations of different organs in mice. Zinc and iron concentrations were measured in pure water, tap water, mineral water and filtered tap-water, respectively. 80 ICR mice (half male and half female) were randomly divided into four groups and fed with pure water (control group), tap water, mineral water and filtered tap-water, respectively. After 90 days, blood samples were taken from the eyeballs of mice. The contents of serum ALT, TP, BUN, UA and Cr were analyzed. Then mice were killed and livers, kidneys, hearts, pancreas, brains were removed immediately to determinate zinc and iron concentrations. Simultaneously morphological changes of liver and kidney paraffin section were observed. Contents of serum Cr in filtered tapwater group (36. 00 ± 8. 83 µmol/L) were lower than those of pure water group(44. 83 ± 12. 64 µmol/L), tap water group (44. 56 ± 10. 52 µmo/L) and mineral water group (43. 79 ± 10. 53 µmo
ISSN:1000-8020