High-risk factors for parenteral nutrition-associated cholestasis in very low birth weight infants

To investigate the high-risk factors for parenteral nutrition-associated cholestasis (PNAC), which is the most common complication of parenteral nutrition for infants, in very low birth weight infants (VLBWIs). Retrospective analysis was performed on the clinical and laboratory data of 204 VLBWIs wh...

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Bibliographic Details
Published inZhongguo dang dai er ke za zhi Vol. 14; no. 10; p. 733
Main Authors Zhu, Mei-Ying, Gu, Min-Zhen
Format Journal Article
LanguageChinese
Published China 01.10.2012
Subjects
Cholestasis - etiology
Cholestasis - prevention & control
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Logistic Models
Parenteral Nutrition - adverse effects
Risk Factors
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Summary:To investigate the high-risk factors for parenteral nutrition-associated cholestasis (PNAC), which is the most common complication of parenteral nutrition for infants, in very low birth weight infants (VLBWIs). Retrospective analysis was performed on the clinical and laboratory data of 204 VLBWIs who received parenteral nutrition for over 2 weeks in the neonatal intensive care unit from August 2006 to December 2011. The infants'liver function was evaluated periodically before and after Parenteral nutrition. Univariate analysis and multivariate analysis were performed in the observation (PNAC) and control (without PNAC) groups. PNAC occurred in 46 (22.5%) of the 204 VLBWIs. Univariate analysis showed that continuous positive airway pressure (CPAP) ventilation, respiration failure, respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) were significantly increased in the observation group compared with the control group. The observation group had lower birth w
ISSN:1008-8830