Study on alkaloids of Corydalis ochotensis and their antitumor bioactivity

To investigate the chemical constituents of Corydalis ochotensis and their antitumor bioactivity. The compounds were isolated by silica gel column chromatography and recrystallization. Their structures were identified by spectroscopic analysis (NMR) and physicochemical properties. Their cytotoxic ac...

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Bibliographic Details
Published inZhong yao cai Vol. 37; no. 10; p. 1795
Main Authors Yu, Jia-jia, Cong, Deng-li, Jiang, Ying, Zhou, Yuan, Wang, Yan, Zhao, Chun-fang
Format Journal Article
LanguageChinese
Published China 01.10.2014
Subjects
Alkaloids - isolation & purification
Alkaloids - pharmacology
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Benzophenanthridines
Berberine - analogs & derivatives
Berberine Alkaloids
Cell Line, Tumor - drug effects
Corydalis - chemistry
Humans
Isoquinolines
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Summary:To investigate the chemical constituents of Corydalis ochotensis and their antitumor bioactivity. The compounds were isolated by silica gel column chromatography and recrystallization. Their structures were identified by spectroscopic analysis (NMR) and physicochemical properties. Their cytotoxic activity was studied by MTT. Six compounds were elucidated as protopine (1), ochotensimine (2), fumariline (3), sanguinarine (4), tetrahydroberberine (5) and berberine (6). Compound 1 had excellent inhibitory activity on HepG2, SW480 and A549 cells, and compound 4 had excellent inhibitory activity on Hep2, HepG2, SW480 and A549 cells. Compounds 3, 4 and 5 are isolated from this plant for the first time; In the MTT antitumor experiments,compounds 1 and 4 show an antitumor activity.
ISSN:1001-4454